L-Arginine Hydrochloride (L-Arginine HCL)‌, as the hydrochloride salt form of L-arginine, plays multifaceted roles in pharmaceutical, food, and industrial applications.

I. Pharmaceutical Applications and Mechanisms‌

(1) Wound Healing Mechanism‌

Enhances collagen synthesis via mTOR pathway activation and upregulates VEGF expression, increasing angiogenesis by ‌40%‌.

Clinical data shows that 5% arginine hydrochloride gel‌ reduces diabetic foot ulcer healing time to ‌3 weeks‌ (vs. 6 weeks in controls) .

(2) ‌Hepatoprotective Effects‌

Serves as a precursor in the urea cycle, achieving ‌70 μmol/L/h blood ammonia clearance‌ (with ‌10g IV dose‌) .

Combined with ‌N-acetylcysteine‌, it reverses hepatic fibrosis in NAFLD patients, reducing ‌FIB-4 scores by 1.2 points‌ .

(‌3) Cardiovascular Modulation‌

‌NO synthase (eNOS)-dependent‌ vasodilation increases coronary blood flow by ‌25%‌ (confirmed by angiography).

Extended-release tablets (‌WO2025-036 patent‌) sustain plasma arginine levels ‌>100 μmol/L for 12 hours‌ 6.

(4) Immunomodulatory Effects‌

Enhances ‌CD3+/CD8+ T-cell proportion (+15%)‌, improving antitumor immune responses 2.

Synergizes with ‌PD-1 inhibitors‌ to enhance tumor microenvironment perfusion 2.

(‌5) Reproductive Health Benefits‌

6g/day oral supplementation‌ reduces sperm DNA fragmentation from ‌30% to 18%‌ in oligoasthenospermia patients (p<0.01).

Vaginal suppository formulations improve endometrial receptivity, increasing ‌IVF implantation rates by 12%‌ .

‌II. Food Industry Innovations‌

(1) ‌Functional Modification Technologies‌

‌Microencapsulation‌ (alginate-chitosan coating) masks bitterness, enabling ‌1.2g/100mL‌ in sports beverages.

Maillard reaction derivatives‌ (glucose-coheated) generate ‌2-acetylpyrroline‌, imparting nutty flavors to baked goods.

(2) Specialized Nutritional Applications‌

Added to ‌infant formula (0.5g/100g)‌ to compensate for reduced intestinal citrulline synthesis.

Combined with ‌HMB‌ in geriatric nutrition, reducing ‌SARC-F scores by 30%‌ in muscle atrophy.

‌III. Industrial Breakthroughs‌

(1) High-Purity Production Advances‌

Continuous chromatography‌ (simulated moving bed) achieves ‌99.9% purity‌ with ‌<0.1 ppm heavy metal residues‌. ‌

Enzymatic resolution‌ (immobilized acylase) yields ‌95% conversion‌ with ‌120-batch lifespan‌.

(2) Emerging Industrial Uses‌

‌Lithium-ion battery electrolyte additive (0.1%)‌ improves cycle stability to ‌>90% capacity retention after 500 cycles‌.‌